404 Novel glycerin compounds improve skin health

Novel glycerin compounds (NGCs) were developed which generated new reaction products, endoperoxide derivatives. NGCs have been reported to exhibit various biological effects. In addition their deodorizing, disinfecting and antiviral effects, found promote wound healing in the skin by stimulating epithelial growth regeneration with synthesis of extracellular matrix such as hyaluronic acid. this study, order clarify effects on normal human skin, we quantified mRNA gene expression heme oxygenase-1 (HO-1) DAD(P)H quinone dehydrogenase 1 (NQO-1) antioxidant factors PR-PCR protein content intracellular glutathione (GSH) using a culture system epidermal keratinocyte. Moreover, related barrier functions (involucrin (INV), filaggrin (FLG), serine palmitoyl transferase (SPT)) was examined cell differentiation. Our results showed that enhanced HO-1, NQO-1 GSH concentration-dependent manner from 20 ppm after 24 h stimulation. These suggest oxidative property activates Nrf2 (NF-E2-related factor 2) transcription factor, is defense sensor, induces factors. Since caused stimulation at low concentrations NGCs, it strongly suggested hormesis effect would be working protectively for skin. Consistent this, INV, FLG, SPT genes also increased NGCs: FLG threefold increase compared control group. differentiation positive functions. Mild NGC may lead healthy through effect. We are currently conducting detailed analysis three-dimensional cultures epidermis.